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Article

Role of RNA secondary structure of the iron-responsive element in translational regulation of ferritin synthesis.

Nucleic acids research - 25 Oct 1995

Kikinis Z, Eisenstein R S, Bettany A J, Munro H N

Abstract excerpt

Iron regulates synthesis of the iron storage protein ferritin at the translational level through interaction between a stem-loop structure, the iron-responsive element (IRE), located in the 5'-untranslated region (5'-UTR) of ferritin mRNAs, and a protein, the iron regulatory protein (IRP). The role of IRE secondary structure in translational regulation of ferritin synthesis was explored by introducing ferritin...

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PMID: 7479083
DOI: 10.1093/nar/23.20.4190
PMCID: PMC307361

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