Article
Role of RNA secondary structure of the iron-responsive element in translational regulation of ferritin synthesis.
Nucleic acids research - 25 Oct 1995
Kikinis Z, Eisenstein R S, Bettany A J, Munro H N
Abstract excerpt
Iron regulates synthesis of the iron storage protein ferritin at the translational level through interaction between a stem-loop structure, the iron-responsive element (IRE), located in the 5'-untranslated region (5'-UTR) of ferritin mRNAs, and a protein, the iron regulatory protein (IRP). The role of IRE secondary structure in translational regulation of ferritin synthesis was explored by introducing ferritin...
Topics
- Animals
- Base Sequence
- Cell Line
- Chelating Agents
- Deferoxamine
- Ferritins
- Fibroblasts
- Genes, Reporter
- Heme
- Iron
- Molecular Sequence Data
- Mutation