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Article

A phosphomimetic mutation at Ser-138 renders iron regulatory protein 1 sensitive to iron-dependent degradation.

Molecular and cellular biology - 1 Oct 2003

Fillebeen Carine, Chahine Danielle, Caltagirone Annie, Segal Phillip, Pantopoulos Kostas

Abstract excerpt

Iron regulatory protein 1 (IRP1) binds to mRNA iron-responsive elements (IREs) and thereby controls the expression of IRE-containing mRNAs. In iron-replete cells, assembly of a cubane [4Fe-4S] cluster inhibits IRE-binding activity and converts IRP1 to a cytosolic aconitase. Earlier experiments with Saccharomyces cerevisiae suggested that phosphomimetic mutations of Ser-138 negatively affect the stability of the...

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Identifiers

PMID: 12972614
DOI: 10.1128/MCB.23.19.6973-6981.2003
PMCID: PMC193948

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A phosphomimetic mutation at Ser-138 renders iron regulatory protein 1 sensitive to iron-dependent degradation.PMID 12972614Read ↗

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