Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overexpression of iron regulatory protein 1 suppresses growth of tumor xenografts.

Carcinogenesis - 1 Apr 2007

Chen Guohua, Fillebeen Carine, Wang Jian, Pantopoulos Kostas

Abstract excerpt

Iron is essential for proliferation of normal and neoplastic cells. Cellular iron uptake, utilization and storage are regulated by transcriptional and post-transcriptional mechanisms. We hypothesized that the disruption of iron homeostasis may modulate the growth properties of cancer cells. To address this, we employed H1299 lung cancer cells engineered for tetracycline-inducible overexpression of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aconitate Hydratase
Share to Electrophoretic Mobility Shift Assay
Share to Ferritins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Nude

Share to Spectrophotometry, Atomic

Share to Transplantation, Heterologous

Share to Up-Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 17127713
DOI: 10.1093/carcin/bgl210
PMCID: PMC2925110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpression of iron regulatory protein 1 suppresses growth of tumor xenografts.PMID 17127713Read ↗

Expression of a constitutive mutant of iron regulatory protein 1 abolishes iron homeostasis in mammalian cells.Semantic proximity Read ↗

Distinct TP53 Mutation Types Exhibit Increased Sensitivity to Ferroptosis Independently of Changes in Iron Regulatory Protein Activity.Semantic proximity Read ↗

Inhibition of IRP2-dependent reprogramming of iron metabolism suppresses tumor growth in colorectal cancerSemantic proximity Read ↗

Iron-dependent degradation of apo-IRP1 by the ubiquitin-proteasome pathway.Semantic proximity Read ↗

Iron Regulatory Protein 2 Exerts its Oncogenic Activities by Suppressing TAp63 ExpressionSemantic proximity Read ↗

Thioredoxin reductase 1 deficiency reverses tumor phenotype and tumorigenicity of lung carcinoma cells.Semantic proximity Read ↗

Do cancer cells selectively mutate HFE to increase their intracellular iron?Semantic proximity Read ↗

Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis.Semantic proximity Read ↗

Iron-dependent degradation of IRP2 requires its C-terminal region and IRP structural integrity.Semantic proximity Read ↗

Characterization of an iron-dependent regulatory sequence involved in the transcriptional control of AtFer1 and ZmFer1 plant ferritin genes by iron.Semantic proximity Read ↗

IRP1 Ser-711 is a phosphorylation site, critical for regulation of RNA-binding and aconitase activities.Semantic proximity Read ↗

Identification of RNA-binding surfaces in iron regulatory protein-1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.