Article
Post-transcriptional control via iron-responsive elements: the impact of aberrations in hereditary disease.
Mutation research - 1 Nov 1999
Mikulits W, Schranzhofer M, Beug H, Müllner E W
Abstract excerpt
Tight regulation of iron metabolism is crucial to avoid formation of deleterious radicals and is mainly executed at the post-transcriptional level. The regulatory loops are exerted by trans-acting iron regulatory proteins (IRPs) and cis-acting stem-loop motifs, termed iron-responsive elements (IREs), located in the untranslated regions (UTRs) of target mRNAs. Iron scarcity induces binding of IRPs to a single IRE...
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