Article
Quantitative analysis of dose- and time-dependent promotion of four phenotypes of altered hepatic foci by 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Sprague-Dawley rats.
Toxicological sciences : an official journal of the Society of Toxicology - 1 Oct 1999
Teeguarden J G, Dragan Y P, Singh J, Vaughan J, Xu Y H, Goldsworthy T, Pitot H C
Abstract excerpt
Determining both the mechanism by which 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) acts as a tumor promoter and the shape of the dose-response curve at low doses remains an important goal of risk-assessment-directed research. In this report, we extend previous mechanistic and descriptive work done on the effect of TCDD on promotion in the two-stage model of hepatocarcinogenesis, to include lower, more clinically...
Topics
- Alkylating Agents
- Animals
- Carcinogens
- Diethylnitrosamine
- Dose-Response Relationship, Drug
- Female
- Glutathione Transferase
- Liver
- Liver Neoplasms
- Organ Size
- Phenotype
- Polychlorinated Dibenzodioxins
- Precancerous Conditions