Article
Risk assessment of non-genotoxic carcinogens.
Toxicology letters - 1 Dec 1992
Moolgavkar S H, Luebeck E G
Abstract excerpt
Rates of cell proliferation, cell death, and cell differentiation affect the risk of cancer profoundly. An increase in cell proliferation rates leads to an increase in mutation rates per unit of time, which, in turn, leads to an increase in the risk of cancer. An increase in cell division rates relative to death or differentiation rates may lead to an increase in the population of critical target cells, which,...
Topics
- Animals
- Cell Death
- Cell Division
- Humans
- Models, Biological
- Mutation
- Neoplasms
- Risk Factors