Effects of polychlorinated biphenyls in rat liver: quantitative analysis of enzyme-altered foci.

doi:10.1016/0041-008x(91)90251-9

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Article

Effects of polychlorinated biphenyls in rat liver: quantitative analysis of enzyme-altered foci.

Toxicology and applied pharmacology - 1 Dec 1991

Luebeck E G, Moolgavkar S H, Buchmann A, Schwarz M

Abstract excerpt

The promotional effect of various polychlorinated biphenyls and phenobarbital on enzyme-altered lesions in the rat liver was quantified within the framework of the two-stage carcinogenesis model of Moolgavkar and colleagues. The experiment analyzed here followed an initiation-promotion protocol in which female Wistar rats were initiated with diethylnitrosamine (DEN) at 10 mg/kg body wt for 10 days followed by a...

Topics

Adenosine Triphosphatases
Animals
Cell Cycle
Cell Division
Cell Transformation, Neoplastic
Diethylnitrosamine
Female
Liver
Liver Neoplasms, Experimental
Mathematics
Models, Biological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Polychlorinated Biphenyls

Rats

Rats, Inbred Strains

Statistics as Topic

Time Factors

gamma-Glutamyltransferase

Source

Open in PubMed

Identifiers

PMID: 1684071
DOI: 10.1016/0041-008x(91)90251-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1684071-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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