Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An initiation-promotion assay in rat liver as a potential complement to the 2-year carcinogenesis bioassay.

Fundamental and applied toxicology : official journal of the Society of Toxicology - 1 Apr 1991

Dragan Y P, Rizvi T, Xu Y H, Hully J R, Bawa N, Campbell H A, Maronpot R R, Pitot H C

Abstract excerpt

Several pharmaceutical agents, manufacturing chemicals, and environmental contaminants were found to act primarily as promoting agents in an initiation-promotion paradigm. The phenotypic distribution of four enzyme markers--placental glutathione-S-transferase (PGST), gamma-glutamyl transpeptidase (GGT), canalicular ATPase (ATPase), and glucose-6-phosphatase (G6Pase)--was analyzed in altered hepatic foci (AHF) by...

Topics

Animals
Carcinogenicity Tests
Diet
Female
Liver
Liver Neoplasms, Experimental
Male
Molecular Conformation
Naphthols
Norbornanes
Phenobarbital

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Polychlorinated Dibenzodioxins

Rats

Rats, Inbred F344

Sex Factors

Source

Identifiers

PMID: 1855624
DOI: 10.1016/0272-0590(91)90093-j

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1855624-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An initiation-promotion assay in rat liver as a potential complement to the 2-year carcinogenesis bioassay.PMID 1855624Read ↗

Effects of polychlorinated biphenyls in rat liver: quantitative analysis of enzyme-altered foci.Semantic proximity Read ↗

Quantitative analysis of dose- and time-dependent promotion of four phenotypes of altered hepatic foci by 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Sprague-Dawley rats.Semantic proximity Read ↗

Quantitative analysis of multiple phenotype enzyme-altered foci in rat hepatocarcinogenesis experiments: the multipath/multistage model.Semantic proximity Read ↗

The effect of the format of administration and the total dose of phenobarbital on altered hepatic foci following initiation in female rats with diethylnitrosamine.Semantic proximity Read ↗

Comparison of hepatocyte phenotypes at the glutathione transferase and albumin loci in Sprague-Dawley and Nagase analbuminemic rats and F1 progeny after initiation and promotion.Semantic proximity Read ↗

Quantitation of Multistage Carcinogenesis in Rat LiverSemantic proximity Read ↗

Role of cell proliferation at early stages of hepatocarcinogenesis.Semantic proximity Read ↗

Evaluation of Possible Carcinogenic Risk to Humans Based on Liver Tumors in Rodent AssaysSemantic proximity Read ↗

Analysis of rat liver foci growth with a quantitative two-cell model after treatment with 2,4,5,3',4'-pentachlorobiphenyl.Semantic proximity Read ↗

Improvement and validation of a medium-term gpt delta rat model for predicting chemical carcinogenicity and underlying mode of action.Semantic proximity Read ↗

Hepatic foci in rats after diethylnitrosamine initiation and 2,3,7,8-tetrachlorodibenzo-p-dioxin promotion: evaluation of a quantitative two-cell model and of CYP 1A1/1A2 as a dosimeter.Semantic proximity Read ↗

Biochemical markers associated with the stages of promotion and progression during hepatocarcinogenesis in the rat.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.