Article
Hepatic foci in rats after diethylnitrosamine initiation and 2,3,7,8-tetrachlorodibenzo-p-dioxin promotion: evaluation of a quantitative two-cell model and of CYP 1A1/1A2 as a dosimeter.
Toxicology and applied pharmacology - 1 Oct 1997
Conolly R B, Andersen M E
Abstract excerpt
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a potent hepatic tumor promoter in female rats. We used a quantitative, stochastic initiation-promotion model based on R. B. Conolly and J. S. Kimbell (Toxicol. Appl. Pharmacol. 124, 284-295, 1994) to analyze initiation-promotion results from a previo...
Topics
- Animals
- Apoptosis
- Carcinogens
- Computer Simulation
- Cytochrome P-450 CYP1A1
- Cytochrome P-450 CYP1A2
- Diethylnitrosamine
- Dose-Response Relationship, Drug
- Female
- Gene Expression Regulation, Enzymologic
- Liver
- Liver Neoplasms, Experimental
- Models, Biological
- Mutation
- Polychlorinated Dibenzodioxins
- Rats
- Retrospective Studies