Article
Short-term fasting and the reversal of the stage of promotion in rat hepatocarcinogenesis: role of cell replication, apoptosis, and gene expression.
Toxicological sciences : an official journal of the Society of Toxicology - 1 Dec 1999
Hikita H, Vaughan J, Babcock K, Pitot H C
Abstract excerpt
Studies of the multistage nature of hepatocarcinogenesis in the rat have led to the development of models having significant potential application to carcinogenesis in other tissues as well as other species. Whereas the initial and final stages of carcinogenesis-initiation and progression-involve genetic changes and are operationally irreversible, the intermediate stage of promotion is operationally reversible...
Topics
- Animals
- Apoptosis
- Carcinogens
- Cell Division
- Cell Transformation, Neoplastic
- Fasting
- Female
- Food
- Gene Expression Regulation, Neoplastic
- Liver
- Liver Neoplasms
- Models, Biological
- Nafenopin
- Phenotype
- Rats
- Rats, Sprague-Dawley