Article
Biochemical, pathologic and morphometric alterations induced in male B6C3F1 mouse liver by short-term exposure to dichloroacetic acid.
Toxicology letters - 1 Nov 1995
Carter J H, Carter H W, DeAngelo A B
Abstract excerpt
Dichloroacetic acid (DCA) is a complete hepatocarcinogen and tumor promoter in the male B6C3F1 mouse. Published reports indicate that the compound is non-genotoxic. This study examines possible non-genotoxic (epigenetic) mechanisms by which DCA elicits its carcinogenic response. Correlative bioch...
Topics
- Analysis of Variance
- Animals
- Autoradiography
- Binding Sites
- Body Weight
- Carcinogens
- Cell Division
- DNA
- DNA Damage
- Dichloroacetic Acid
- Dose-Response Relationship, Drug
- Drinking
- Giant Cells
- Hypertrophy
- Image Processing, Computer-Assisted
- Liver
- Male
- Mice