Dehydroepiandrosterone is a complete hepatocarcinogen and potent tumor promoter in the absence of peroxisome proliferation in rainbow trout.

doi:10.1093/carcin/16.12.2893

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Article

Dehydroepiandrosterone is a complete hepatocarcinogen and potent tumor promoter in the absence of peroxisome proliferation in rainbow trout.

Carcinogenesis - 1 Dec 1995

Orner G A, Mathews C, Hendricks J D, Carpenter H M, Bailey G S, Williams D E

Abstract excerpt

Dehydroepiandrosterone (DHEA), fed for 30 weeks to rainbow trout after initiation with the hepatocarcinogen aflatoxin B1 (AFB1), produced a dose-dependent enhancement of carcinogenesis as measured by increased tumor incidence, multiplicity and size. Significant enhancement was observed at 222 p.p...

Topics

Aflatoxin B1
Animals
Carcinogens
Cocarcinogenesis
Dehydroepiandrosterone
Genes, ras
Liver Neoplasms, Experimental
Microbodies
Mutation
Oncorhynchus mykiss

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