Chronic low-dose lesion equilibrium along genes: measurement, molecular epidemiology, and theory of the minimal relevant dose.

doi:10.1016/s0027-5107(98)00132-8

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Article

Chronic low-dose lesion equilibrium along genes: measurement, molecular epidemiology, and theory of the minimal relevant dose.

Mutation research - 20 Sept 1998

Holmquist G P

Abstract excerpt

Spontaneous mutations seem to be caused almost entirely by endogenous lesions. The pattern of these lesions along a gene represents an equilibrium between damage and repair. A pattern can be measured using ligation-mediated PCR (polymerase chain reaction) and a large chronic dose of a suspected e...

Topics

DNA Adducts
DNA Damage
DNA Repair
Dose-Response Relationship, Drug
Guanosine
Humans
Male
Models, Genetic
Molecular Epidemiology
Mutagenesis
Mutagens
Mutation
Neoplasms
Sulfuric Acid Esters

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