Article
No evidence for transgenerational genomic instability in the F1 or F2 descendants of Muta™Mouse males exposed to N-ethyl-N-nitrosourea.
Mutation research - 1 Jan 2000
O'Brien Jason M, Williams Andrew, Gingerich John, Douglas George R, Marchetti Francesco, Yauk Carole L
Abstract excerpt
Exposure of male mice to genotoxic agents can increase mutation frequencies in their unexposed descendants. This phenomenon, known as transgenerational genomic instability (TGI), can persist for several generations. However, little is known about the underlying mechanisms. Chemically-induced TGI has been demonstrated in non-coding unstable tandem repeat DNA regions, but it is unclear whether it extends to other...
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