Gene-mutation assays in lambda lacZ transgenic mice: comparison of lacZ with endogenous genes in splenocytes and small intestinal epithelium.

doi:10.1016/s1383-5718(98)00063-1

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Article

Gene-mutation assays in lambda lacZ transgenic mice: comparison of lacZ with endogenous genes in splenocytes and small intestinal epithelium.

Mutation research - 8 Jul 1998

van Delft J H, Bergmans A, van Dam F J, Tates A D, Howard L, Winton D J, Baan R A

Abstract excerpt

Comparison of results derived from transgenic animal gene-mutation assays with those from mutation analyses in endogenous genes is an important step in the validation of the former. We have used lambda lacZ transgenic mice to study alkylation-induced mutagenesis in vivo in (a) lacZ and hprt in sp...

Topics

Alkylating Agents
Animals
Ethyl Methanesulfonate
Ethylnitrosourea
Genetic Markers
Hypoxanthine Phosphoribosyltransferase
Intestinal Mucosa
Intestine, Small
Lac Operon
Methylnitrosourea
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C57BL

Mice, Transgenic

Mutagenicity Tests

Mutagens

Mutation

Spleen

Source

Open in PubMed

Identifiers

PMID: 9711265
DOI: 10.1016/s1383-5718(98)00063-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9711265-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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