Article
On a randomization procedure in linkage analysis.
American journal of human genetics - 1 Nov 1999
Zhao H, Merikangas K R, Kidd K K
Abstract excerpt
Although much theoretical work has been undertaken to derive thresholds for statistical significance in genetic linkage studies, real data are often complicated by many factors, such as missing individuals or uninformative markers, which make the validity of these theoretical results questionable. Many simulation-based methods have been proposed in the literature to determine empirically the statistical...
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