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Article

A randomization test for controlling population stratification in whole-genome association studies.

American journal of human genetics - 1 Nov 2007

Kimmel Gad, Jordan Michael I, Halperin Eran, Shamir Ron, Karp Richard M

Abstract excerpt

Population stratification can be a serious obstacle in the analysis of genomewide association studies. We propose a method for evaluating the significance of association scores in whole-genome cohorts with stratification. Our approach is a randomization test akin to a standard permutation test. It conditions on the genotype matrix and thus takes into account not only the population structure but also the complex...

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Identifiers

PMID: 17924333
DOI: 10.1086/521372
PMCID: PMC2265648

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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