Article
Mendelian Randomization using Public Data from Genetic Consortia.
The international journal of biostatistics - 1 Nov 2016
Thompson John R, Minelli Cosetta, Del Greco M Fabiola
Abstract excerpt
Mendelian randomization (MR) is a technique that seeks to establish causation between an exposure and an outcome using observational data. It is an instrumental variable analysis in which genetic variants are used as the instruments. Many consortia have meta-analysed genome-wide associations between variants and specific traits and made their results publicly available. Using such data, it is possible to derive...
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