Article
A more powerful method to evaluate p-values in GENEHUNTER.
Genetic epidemiology - 1 Jan 1999
Zhao H, Sheffield L J, Pakstis A J, Knauert M P, Kidd K K
Abstract excerpt
The determination of statistical significance in genetic linkage studies is complicated by many factors, such as missing individuals or uninformative markers, and the validity of theoretical results is often questionable. Although many simulation-based methods have been proposed to determine empirically the statistical significance, they are either not generally applicable to complex pedigree structures, or not...
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