Article
Randomization tests of disease-marker associations.
Annals of human genetics - 1 Jan 1997
Morris A P, Curnow R N, Whittaker J C
Abstract excerpt
A powerful test for population association of a disease with alleles at a bi-allelic marker locus is the transmission/disequilibrium test (TDT). A generalization of the test to multi-allelic marker loci is proposed which utilizes the maximal association of individual alleles with the disease, given by the maximum TDT statistic, TDT(max). To overcome the multiple testing problem encountered when using the maximal...
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