Article
Ricin cytotoxicity is sensitive to recycling between the endoplasmic reticulum and the Golgi complex.
The Journal of biological chemistry - 25 Aug 1995
Simpson J C, Dascher C, Roberts L M, Lord J M, Balch W E
Abstract excerpt
Cytotoxic proteins that kill mammalian cells by catalytically inhibiting protein synthesis must enter the cytosol in order to reach their substrates. With the exception of diphtheria toxin, which enters the cytosol from acidified endosomes, the intracellular site of translocation of other toxins including ricin, Escherichia coli Shiga-like toxin-1, and Pseudomonas exotoxin A is likely to involve early...
Topics
- Amino Acid Sequence
- Biological Transport, Active
- Cell Death
- Endocytosis
- Endoplasmic Reticulum
- Exocytosis
- GTP Phosphohydrolases
- Gene Expression
- Golgi Apparatus
- HeLa Cells
- Humans