Retrograde transport of mutant ricin to the endoplasmic reticulum with subsequent translocation to cytosol.

doi:10.1073/pnas.94.8.3783

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Article

Retrograde transport of mutant ricin to the endoplasmic reticulum with subsequent translocation to cytosol.

Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 1997

Rapak A, Falnes P O, Olsnes S

Abstract excerpt

Translocation of ricin A chain to the cytosol has been proposed to take place from the endoplasmic reticulum (ER), but attempts to visualize ricin in this organelle have failed. Here we modified ricin A chain to contain a tyrosine sulfation site alone or in combination with N-glycosylation sites....

Topics

Animals
Base Sequence
Biological Transport
Chlorocebus aethiops
Cytosol
Endoplasmic Reticulum
Golgi Apparatus
Molecular Sequence Data
Mutation
Plasmids
Ricin
Vero Cells

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