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Article

Retrograde transport of mutant ricin to the endoplasmic reticulum with subsequent translocation to cytosol.

Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 1997

Rapak A, Falnes P O, Olsnes S

Abstract excerpt

Translocation of ricin A chain to the cytosol has been proposed to take place from the endoplasmic reticulum (ER), but attempts to visualize ricin in this organelle have failed. Here we modified ricin A chain to contain a tyrosine sulfation site alone or in combination with N-glycosylation sites. When reconstituted with ricin B chain and incubated with cells in the presence of Na(2)(35)SO(4), the modified A...

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Identifiers

PMID: 9108055
DOI: 10.1073/pnas.94.8.3783
PMCID: PMC20518

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Source receipt: pubmed, retrieved 7 Sept 2026.

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