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Article

Retrotranslocation of a viral A/B toxin from the yeast endoplasmic reticulum is independent of ubiquitination and ERAD.

The EMBO journal - 18 Oct 2006

Heiligenstein Susanne, Eisfeld Katrin, Sendzik Tanja, Jimenéz-Becker Natalia, Breinig Frank, Schmitt Manfred J

Abstract excerpt

K28 is a viral A/B toxin that traverses eukaryotic cells by endocytosis and retrograde transport through the secretory pathway. Here we show that toxin retrotranslocation from the endoplasmic reticulum (ER) requires Kar2p/BiP, Pdi1p, Scj1p, Jem1p, and proper maintenance of Ca(2+) homeostasis. Neither cytosolic chaperones nor Cdc48p/Ufd1p/Npl4p complex components or proteasome activity are required for ER exit,...

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Identifiers

PMID: 17006544
DOI: 10.1038/sj.emboj.7601350
PMCID: PMC1618096

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Source receipt: pubmed, retrieved 7 Sept 2026.

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