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Article

A yeast killer toxin screen provides insights into a/b toxin entry, trafficking, and killing mechanisms.

Developmental cell - 1 Oct 2009

Carroll Susheela Y, Stirling Peter C, Stimpson Helen E M, Giesselmann Esther, Schmitt Manfred J, Drubin David G

Abstract excerpt

Like Ricin, Shiga, and Cholera toxins, yeast K28 is an A/B toxin that depends on endocytosis and retrograde trafficking for toxicity. Knowledge of the specific proteins, lipids, and mechanisms required for trafficking and killing by these toxins remains incomplete. Since K28 is a model for clinically relevant toxins, we screened over 5000 yeast mutants, identifying 365 that affect K28 sensitivity. Hypersensitive...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 19853568
DOI: 10.1016/j.devcel.2009.08.006
PMCID: PMC2768656

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GPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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