Article
Cyclin D1, glutathione S-transferase, and cytochrome P450 genotypes and outcome in patients with upper aerodigestive tract cancers: assessment of the importance of individual genes using multivariate analysis.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Sept 1999
Matthias C, Jahnke V, Jones P W, Hoban P R, Alldersea J E, Worrall S F, Fryer A A, Strange R C
Abstract excerpt
GST, CYP, and CCND1 genotypes have been associated with outcome in several cancers. Accordingly, we have examined, in patients with one squamous cell carcinoma (SCC) of the head and neck, associations between GSTM1, GSTT1, GSTM3, GSTP1, CYP2D6, CYP1A1, CYP2E1, and CCND1 genotypes and the outcome parameters, tumor extension, histological grade, and presence of nodes. We used logistic regression to study, first,...
Topics
- Carcinoma, Squamous Cell
- Cyclin D1
- Cytochrome P-450 Enzyme System
- Female
- Genotype
- Germany
- Glutathione Transferase
- Humans
- Laryngeal Neoplasms
- Male
- Middle Aged
- Multivariate Analysis