Article
Cyclin D1 polymorphism and expression in patients with squamous cell carcinoma of the head and neck.
The American journal of pathology - 1 Nov 2001
Holley S L, Parkes G, Matthias C, Bockmühl U, Jahnke V, Leder K, Strange R C, Fryer A A, Hoban P R
Abstract excerpt
We have previously reported that the cyclin D1 (CCND1) GG870 genotype was associated with poorly differentiated tumors and reduced disease-free interval in patients with squamous cell carcinoma of the head and neck (SCCHN). We have now examined the association of this and a second CCND1 polymorphism with gene expression and outcome in SCCHN patients. Analysis of a CCND1 G/C1722 polymorphism revealed that CCND1...
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