Article
Polymorphisms of GSTT1 and related genes in head and neck cancer risk.
Head & neck - 1 Jan 2004
Evans Adam J, Henner William David, Eilers Kristi M, Montalto Michelle A, Wersinger Emily M, Andersen Peter E, Cohen James I, Everts Edwin C, McWilliams Jeffrey E, Beer Tomasz M
Abstract excerpt
BACKGROUND: Glutathione S-transferase T1 detoxifies some environmental carcinogens while activating others and is deleted in 15% to 38% of humans. We sought to determine whether GSTT1 genotype and genotypes of several related genes are associated with risk of squamous cell carcinoma of the head and neck (HNSCC). METHODS: Somatic genotypes for GSTT1, GSTM1, GSTP1, and CYP1A1 were determined in 283 individuals with...
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