Article
Polymorphism in cytochrome P450 CYP2D6, CYP1A1, CYP2E1 and glutathione S-transferase, GSTM1, GSTM3, GSTT1 and susceptibility to tobacco-related cancers: studies in upper aerodigestive tract cancers.
Pharmacogenetics - 1 Apr 1998
Matthias C, Bockmühl U, Jahnke V, Jones P W, Hayes J D, Alldersea J, Gilford J, Bailey L, Bath J, Worrall S F, Hand P, Fryer A A, Strange R C
Abstract excerpt
Glutathione S-transferase GSTM1, GSTM3 and GSTT1 and cytochrome P450 CYP2D6, CYP1A1 and CYP2E1 loci are susceptibility candidates for cancers of the upper aerodigestive tract because putatively protective and risk genotypes have been identified from studies in other diseases associated with alcohol and tobacco consumption. We describe genotype frequencies in 398 oral, pharyngeal and laryngeal squamous cell...
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