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Article

Susceptibility and outcome in oral cancer: preliminary data showing an association with polymorphism in cytochrome P450 CYP2D6.

Pharmacogenetics - 1 Oct 1998

Worrall S F, Corrigan M, High A, Starr D, Matthias C, Wolf C R, Jones P W, Hand P, Gilford J, Farrell W E, Hoban P, Fryer A A, Strange R C

Abstract excerpt

Members of the cytochrome P450 and glutathione S-transferase supergene families are candidates for susceptibility and outcome in oral squamous cell cancer. We determined GSTM1, GSTM3, GSTT1, CYP1A1 and CYP2D6 genotypes in 100 Caucasian cases and 467 control individuals. The frequency of homozygosity for mutant CYP2D6 alleles was higher in the cases (P = 0.001, OR = 3.2, 95% CI = 1.6-6.5) than control individuals....

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Source

Identifiers

PMID: 9825835
DOI: 10.1097/00008571-199810000-00008

Genes

GSTM1
GSTM3
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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