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Article

The impact of genetic factors on the incidence of multiple primary tumors (MPT) of the head and neck.

Cancer letters - 28 Jun 2005

Rydzanicz Małgorzata, Wierzbicka Małgorzata, Gajecka Marzena, Szyfter Witold, Szyfter Krzysztof

Abstract excerpt

One of the most troublesome failures in head and neck tumors treatment is the incidence of multiple primary tumors (MPT). The aim of the study was to identity the genetic factors associated with the predisposition of second cancer occurrence. The polymorphisms of genes involved in carcinogen metabolic activation (CYP1A1, CYP2E1), detoxication (GSTM1, GSTT1, GSTM3, NAT2,) and DNA repair (XPD /A35931C-exon 23 and...

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Source

Identifiers

PMID: 15914277
DOI: 10.1016/j.canlet.2005.01.015

Genes

GSTM1
GSTM3
GSTT1
NAT2
XRCC1
XRCC3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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