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Article

Dextromethorphan O-demethylation polymorphism in an African-American population.

European journal of clinical pharmacology - 1 Aug 1999

He N, Daniel H I, Hajiloo L, Shockley D

Abstract excerpt

OBJECTIVE: One hundred eighty-one (97 F, 84 M) unrelated healthy African-American subjects (aged 18-41 years) were phenotyped based on their dextromethorphan (DMP) O-demethylation ability. METHODS: Each subject was given 15 mg DMP orally and collected 8-h urine. The concentrations of DMP and its metabolite dextrophan (DOP) were determined by HPLC with ultraviolet detection. Metabolic ratio (MR) was expressed as...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Cytochrome P-450 CYP2D6

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Source

Identifiers

PMID: 10492059
DOI: 10.1007/s002280050656

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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