Polymorphism of dextromethorphan oxidation in South Indian subjects.

doi:10.1053/cp.1999.v66.99989

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Article

Polymorphism of dextromethorphan oxidation in South Indian subjects.

Clinical pharmacology and therapeutics - 1 Aug 1999

Mamidi R N, Satyavageeswaran S, Vakkalanka S V, Chaluvadi M R, Katneni K, Brahmadevara N, Damodarram G, Subramaniam S

Abstract excerpt

One hundred fifty-six unrelated healthy South Indian subjects were phenotyped according to their ability to metabolize dextromethorphan to its O-demethylated metabolite dextrorphan. Each volunteer was administered 25 mg oral dextromethorphan hydrobromide (19.3 mg dextromethorphan). Urine was collected during an 8-hour period after drug administration and was analyzed for dextromethorphan and dextrorphan by HPLC...

Topics

Adolescent
Adult
Chromatography, High Pressure Liquid
Dextromethorphan
Female
Fluorescence
Humans
India
Male
Middle Aged
Oxidation-Reduction
Phenotype
Polymorphism, Genetic

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Open in PubMed

Identifiers

PMID: 10460073
DOI: 10.1053/cp.1999.v66.99989

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