Article
Polymorphism of dextromethorphan oxidation in South Indian subjects.
Clinical pharmacology and therapeutics - 1 Aug 1999
Mamidi R N, Satyavageeswaran S, Vakkalanka S V, Chaluvadi M R, Katneni K, Brahmadevara N, Damodarram G, Subramaniam S
Abstract excerpt
One hundred fifty-six unrelated healthy South Indian subjects were phenotyped according to their ability to metabolize dextromethorphan to its O-demethylated metabolite dextrorphan. Each volunteer was administered 25 mg oral dextromethorphan hydrobromide (19.3 mg dextromethorphan). Urine was collected during an 8-hour period after drug administration and was analyzed for dextromethorphan and dextrorphan by HPLC...
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