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Article

Enzyme polymorphism on the metabolic O-demethylation of dextromethorphan in a South American population.

Medicina - 1 Jan 1996

Estévez F, Giusti M, Parrillo S, Oxandabarat J

Abstract excerpt

The polymorphic oxidative metabolism of debrisoquine and sparteine were discovered in the seventies by Mahgoub and Eichelbaum. Since then, many other therapeutic substances were added and one of these drugs is dextromethorphan. The object of this investigation was to ascertain the distribution of the oxidative phenotype of dextromethorphan in the Uruguayan population. The drug and its metabolite, dextrorphan,...

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PMID: 9138342

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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