Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans.

Clinical pharmacology and therapeutics - 1 Jul 2002

Gaedigk Andrea, Bradford L DiAnne, Marcucci Kenda A, Leeder J Steven

Abstract excerpt

BACKGROUND: Although CYP2D6 has been studied extensively in different population groups, relatively little is known for black Americans. METHODS: CYP2D6 activity was assessed with dextromethorphan in 283 black American subjects and correlated with their genotype (2D6*2 to *12, 2D6*14, 2D6*15, 2D6*17, 2D6*18, and 2D6*29 and gene duplications). Volunteers provided information about ethnicity and concurrent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Black or African American
Share to Black People
Share to COS Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2D6

Share to Dextromethorphan

Share to Kinetics

Share to United States

Share to White People

Source

Identifiers

PMID: 12152006
DOI: 10.1067/mcp.2002.125783

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans.PMID 12152006Read ↗

Identification of CYP2D6 impaired functional alleles in Mexican Americans.Semantic proximity Read ↗

CYP2D6 polymorphism in a Mexican American population.Semantic proximity Read ↗

Comparison of two CYP2D6 genotyping methods and assessment of genotype-phenotype relationships.Semantic proximity Read ↗

In vivo characterization of CYP2D6*12, *29 and *84 using dextromethorphan as a probe drug: a case report.Semantic proximity Read ↗

Genetic basis for a lower prevalence of deficient CYP2D6 oxidative drug metabolism phenotypes in black Americans.Semantic proximity Read ↗

Discovery of novel functional variants and extensive evaluation of CYP2D6 genetic polymorphisms in Koreans.Semantic proximity Read ↗

The effect of CYP2D6 polymorphisms on dextromethorphan metabolism in Mexican Americans.Semantic proximity Read ↗

Identification and characterization of CYP2D6*56B, an allele associated with the poor metabolizer phenotype.Semantic proximity Read ↗

Polymorphism of CYP2D6 in Black populations: implications for psychopharmacologySemantic proximity Read ↗

Analysis of the CYP2D6 gene polymorphism and enzyme activity in African-Americans in southern California.Semantic proximity Read ↗

Discovery of the nonfunctional CYP2D6 31 allele in Spanish, Puerto Rican, and US Hispanic populations.Semantic proximity Read ↗

CYP2D6 polymorphism in a Gabonese population: contribution of the CYP2D6*2 and CYP2D6*17 alleles to the high prevalence of the intermediate metabolic phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.