Article
Frequency distribution of dextromethorphan O-demethylation in a Greek population.
International journal of clinical pharmacology and therapeutics - 1 Mar 2005
Kimiskidis V K, Niopas I, Firinidis P D, Kanaze F I, Gabrieli C, Kazis D, Papagiannopoulos S, Kazis A
Abstract excerpt
OBJECTIVE: To determine the CYP2D6 phenotype in a Greek population by using dextromethorphan (DM) as a probe drug. METHODS: DM (30 mg) was given orally to 102 unrelated Greek subjects and 8-hour urine samples were collected. Concentrations of DM and its metabolite dextrorphan (DX) were determined using a validated HPLC assay. Metabolic molar ratio (MR) of DM to free DX in log form was used as an in vivo index of...
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