Article
Dextromethorphan metabolic phenotyping in a Chinese population.
Zhongguo yao li xue bao = Acta pharmacologica Sinica - 1 Sept 1997
Cai W M, Chen B, Liu Y X, Chu X
Abstract excerpt
AIM: To establish a phenotyping of dextromethorphan (DM) oxidation polymorphism in a native Chinese population. METHODS: The urine concentrations of DM and its metabolite dextrophan (DX) were assayed by HPLC and metabolic ratios (MR) were calculated in 120 unrelated native Chinese subjects after ingestion of DM 20 mg. RESULTS: The incidence of poor metabolizers was 0.8% (one in 120 subjects). There were distinct...
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