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Article

Translational Control by an Upstream Open Reading Frame in the HER-2/neu Transcript

1 Aug 1999

Abstract excerpt

Overexpression of the HER-2 (neu, erbB-2) receptor results in cellular transformation and is associated with a variety of human cancers. Multiple mechanisms, including gene amplification and transcriptional, post-transcriptional, and translational controls contribute to the regulation of HER-2 expression. One of the components of these regulatory mechanisms is a short upstream open reading frame (uORF) in the...

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PMID: 10446211
DOI: 10.1074/jbc.274.34.24335

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