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Article

cis-acting sequences involved in the translational control of GCN4 expression.

Biochimica et biophysica acta - 27 Aug 1990

Miller P F, Hinnebusch A G

Abstract excerpt

Four short upstream open reading frames (uORFs) in the mRNA leader are required for the translational control of GCN4 expression in response to amino acid availability. Data are reviewed demonstrating that the fourth (3' proximal) uORF is sufficient to establish the repressed levels of GCN4 expression, while the first uORF functions as a positive regulatory element under starvation conditions to stimulate GCN4...

Topics

Alleles
Codon
DNA-Binding Proteins
Fungal Proteins
Gene Expression Regulation, Fungal
Protein Biosynthesis
Protein Kinases
RNA, Messenger
Saccharomyces cerevisiae Proteins
Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 2207139
DOI: 10.1016/0167-4781(90)90157-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2207139-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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