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Translation of the human erythropoietin transcript is regulated by an upstream open reading frame in response to hypoxia

19 Mar 2014

Abstract excerpt

Erythropoietin (EPO) is a key mediator hormone for hypoxic induction of erythropoiesis that also plays important nonhematopoietic functions. It has been shown that EPO gene expression regulation occurs at different levels, including transcription and mRNA stabilization. In this report, we show that expression of EPO is also regulated at the translational level by an upstream open reading frame (uORF) of 14...

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PMID: 24647661
DOI: 10.1261/rna.040915.113

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