Article
The cancerous translation apparatus.
Current opinion in genetics & development - 1 Aug 2011
Stumpf Craig R, Ruggero Davide
Abstract excerpt
Deregulations in translational control are critical features of cancer initiation and progression. Activation of key oncogenic pathways promotes rapid and dramatic translational reprogramming, not simply by increasing overall protein synthesis, but also by modulating specific mRNA networks that promote cellular transformation. Additionally, ribosomopathies caused by mutations in ribosome components alter...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
