Article

Toward a model of uORF-mediated translational control: An integrated bioinformatic and experimental approach

2025-07-31

Abstract excerpt

Upstream open reading frames (uORFs) are short translated regions that occur in the 5□ untranslated regions (5□ UTRs) of mRNA transcripts where they primarily serve to repress expression translation of the downstream primary open reading frame (pORF). Their widespread presence across mammalian transcriptomes suggests an important role in shaping the proteome, although the mechanistic basis of their regulatory effe...

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Literature Corpus work: e1f712ff-5ea1-5b92-bbe7-02a46a082d47
DOI: 10.1101/2025.07.28.667205

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