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Article

Loss-of-function uORF mutations in human malignancies.

Scientific reports - 5 Feb 2018

Schulz Julia, Mah Nancy, Neuenschwander Martin, Kischka Tabea, Ratei Richard, Schlag Peter M, Castaños-Vélez Esmeralda, Fichtner Iduna, Tunn Per-Ulf, Denkert Carsten, Klaas Oliver, Berdel Wolfgang E, von Kries Jens P, Makalowski Wojciech, Andrade-Navarro Miguel A, Leutz Achim, Wethmar Klaus

Abstract excerpt

Ribosome profiling revealed widespread translational activity at upstream open reading frames (uORFs) and validated uORF-mediated translational control as a commonly repressive mechanism of gene expression. Translational activation of proto-oncogenes through loss-of-uORF mutations has been demonstrated, yet a systematic search for cancer-associated genetic alterations in uORFs is lacking. Here, we applied a...

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Identifiers

PMID: 29402903
DOI: 10.1038/s41598-018-19201-8
PMCID: PMC5799362

Genes

EPHB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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