Article
Biosynthesis of tumorigenic HER2 C-terminal fragments by alternative initiation of translation.
The EMBO journal - 12 Jul 2006
Anido Judit, Scaltriti Maurizio, Bech Serra Joan Josep, Santiago Josefat Belén, Todo Federico Rojo, Baselga José, Arribas Joaquín
Abstract excerpt
The overactivation of the HERs, a family of tyrosine kinase receptors, leads to the development of cancer. Although the canonical view contemplates HER receptors restricted to the secretory and endocytic pathways, full-length HER1, HER2 and HER3 have been detected in the nucleoplasm. Furthermore, limited proteolysis of HER4 generates nuclear C-terminal fragments (CTFs). Using cells expressing a panel of deletion...
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