Article

Translational buffering by ribosome stalling in upstream open reading frames

2022-01-07

Abstract excerpt

Upstream open reading frames (uORFs) are present in over half of all human mRNAs. uORFs can potently regulate the translation of downstream open reading frames by several mechanisms: siphoning away scanning ribo-somes, regulating re-initiation, and allowing interactions between scanning and elongating ribosomes. However, the consequences of these different mechanisms for the regulation of protein expression remain...

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Literature Corpus work: 602ef900-e396-5c30-b970-e6b66678c0c2
DOI: 10.1101/2022.01.06.475296

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