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Article

The Cdc6 nucleotide-binding site regulates its activity in DNA replication in human cells.

Molecular biology of the cell - 1 Aug 1999

Herbig U, Marlar C A, Fanning E

Abstract excerpt

The Cdc6 protein of budding yeast and its homologues in other species play an essential role in the initiation of DNA replication. A cDNA encoding a human homologue of Cdc6 (HsCdc6) has been cloned and expressed as a fusion protein in a soluble and functionally active form. The purified protein bound specifically to ATP and slowly hydrolyzed it, whereas HsCdc6 mutants containing amino acid substitutions in the...

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Identifiers

PMID: 10436018
DOI: 10.1091/mbc.10.8.2631
PMCID: PMC25495

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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