Article
Multiple mechanisms regulate subcellular localization of human CDC6.
The Journal of biological chemistry - 20 Jul 2001
Delmolino L M, Saha P, Dutta A
Abstract excerpt
CDC6 is a protein essential for DNA replication, the expression and abundance of which are cell cycle-regulated in Saccharomyces cerevisiae. We have demonstrated previously that the subcellular localization of the human CDC6 homolog, HsCDC6, is cell cycle-dependent: nuclear during G(1) phase and cytoplasmic during S phase. Here we demonstrate that endogenous HsCDC6 is phosphorylated during the G(1)/S transition....
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