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Article

Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chk1.

The EMBO journal - 3 Feb 2003

Clay-Farrace Lorena, Pelizon Cristina, Santamaria David, Pines Jonathon, Laskey Ronald A

Abstract excerpt

In yeasts, the replication protein Cdc6/Cdc18 is required for the initiation of DNA replication and also for coupling S phase with the following mitosis. In metazoans a role for Cdc6 has only been shown in S phase entry. Here we provide evidence that human Cdc6 (HuCdc6) also regulates the onset of mitosis, as overexpression of HuCdc6 in G(2) phase cells prevents entry into mitosis. This block is abolished when...

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Source

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Identifiers

PMID: 12554670
DOI: 10.1093/emboj/cdg046
PMCID: PMC140731

Genes

CDK1
UCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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