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Article

Crystal structure of RS21-C6, involved in nucleoside triphosphate pyrophosphohydrolysis.

Journal of molecular biology - 13 Apr 2007

Wu Beili, Liu Yuanfeng, Zhao Qiang, Liao Shuang, Zhang Jun, Bartlam Mark, Chen Weifeng, Rao Zihe

Abstract excerpt

RS21-C6, which is highly expressed in all vertebrate genomes and green plants, is proposed to have nucleoside triphosphate pyrophosphohydrolase activity. Here, we report the crystal structures of the core fragment of RS21-C6, named RSCUT, and the complex with the substrate 5-methyl dCTP. The refined structure of RSCUT consists mainly of alpha-helices and shows formation of a tightly associated tetramer. On the...

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PMID: 17320107
DOI: 10.1016/j.jmb.2007.01.057

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