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CDC6: from DNA replication to cell cycle checkpoints and oncogenesis

28 Nov 2007

Abstract excerpt

Cell division cycle 6 (CDC6) is an essential regulator of DNA replication in eukaryotic cells. Its best-characterized function is the assembly of prereplicative complexes at origins of replication during the G(1) phase of the cell division cycle. However, CDC6 also plays important roles in the activation and maintenance of the checkpoint mechanisms that coordinate S phase and mitosis, and recent studies have...

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PMID: 18048387
DOI: 10.1093/carcin/bgm268

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