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Article

Structure and function of Cdc6/Cdc18: implications for origin recognition and checkpoint control.

Molecular cell - 1 Sept 2000

Liu J, Smith C L, DeRyckere D, DeAngelis K, Martin G S, Berger J M

Abstract excerpt

Cdc6/Cdc18 is a conserved and essential component of prereplication complexes. The 2.0 A crystal structure of an archaeal Cdc6 ortholog, in conjunction with a mutational analysis of the homologous Cdc18 protein from Schizosaccharomyces pombe, reveals novel aspects of Cdc6/Cdc18 function. Two domains of Cdc6 form an AAA+-type nucleotide binding fold that is observed bound to Mg.ADP. A third domain adopts a...

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PMID: 11030343
DOI: 10.1016/s1097-2765(00)00062-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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